Background: Nano-emulsions, as non-equilibrium systems, present characteristics and properties which depend\r\nnot only on composition but also on their method of preparation. To obtain better penetration,\r\nnanocosmeceuticals use nano-sized systems for the delivery of active ingredients to targeted cells. In this work,\r\nnano-emulsions composed of miglyol, rapeseed oil and salmon oil were developed as a cosmetic matrix.\r\nMeasurements of different physico-chemical properties of nano-emulsions were taken according to size,\r\nelectrophoretic mobility, conductivity, viscosity, turbidity, cristallization and melting point. The RHLB was calculated\r\nfor each formulation in order to achieve maximum stability.\r\nResults: Both tween 80 and soya lecithin were found to stabilize formulations. The results showed that rapeseed\r\noil and miglyol are the predominant parameters for determining the expression of results concerning the\r\ncharacterization of emulsion. Based on the mixture design, we achieved the optimal point using the following\r\nformulation: 56.5% rapessed oil, 35.5% miglyol, and 8% salmon oil. We considered this formulation to be the best\r\nas a nanocosmeceutical product due to the small size, good turbidity, and average HLB.\r\nConclusions: This study demonstrates the influence of formulation on the physico-chemical properties of each\r\nnano-emulsion obtained by the mixture design.
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